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Funny Megaman au thought time.
After Wily gets defeated for the first time and subsequently released from prison, Roll starts pranking him. Like she finds him, realizes he's gonna make his own robots, and decides to postpone his plans by being a little turd.
Wily has no knowledge of this and is freaking out over an unseen prankster that seems to have it out for him specifically.
Roll never does anything that causes physical harm, only minor inconveniences that leaves Wily confused and a little scared.
I think it'd be even funnier if Roll didn't tell Rock or Dr. Light, but the Robot Masters figure it out and agree to keep it on the down low if it means they can also prank Wily.