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As it turns out, vagus nerve stimulation may have lasting effects on those with depression. Our vagus nerves run from the brain through the neck and to our internal organs.
An international team of researchers conducted a clinical trial on 493 adults whose major depression hadn't previously responded to treatment, and after nearly ten months of research and heavy assessments, it was found that participants who received the stimulation treatment showed improvements in their depressive symptoms. This was further proven by trial lead by Washington University School of Medicine in St. Louis, which conducted their study on the wider range of 500 participants at 84 sites across the U.S. The patients from both of these clinical trials were previously found to have not been treated effectively with medication or other approaches.
You can actually read more about Vagus Nerve Stimulation here if you're interested;
https://www.brainstimjrnl.com/current