Microbiology!

Watch what happens to Germs when you wash your hands with Soap at microscopic level. 🔬 The Soap molecules surround germ cells and disrupt their cell walls, causing them to burst.

Germ cells are surrounded by a cell wall that protects them from the environment. This cell wall is made up of a layer of peptidoglycan, which is a polymer of amino acids and sugars. Soap molecules are made up of two parts: a hydrophobic (water-fearing) tail and a hydrophilic (water-loving) head. When soap is added to water, the hydrophobic tails group together and the hydrophilic heads face outward, forming micelles. These micelles can surround germ cells and the hydrophobic tails can then disrupt the cell walls, causing the cells to burst.

The hydrophobic tails of the soap molecules can disrupt the cell wall in two ways. First, they can bind to the peptidoglycan molecules and weaken the bonds between them. Second, they can create holes in the cell wall. Once the cell wall is disrupted, the germ cells lose their internal contents and die.

It is important to note that soap only works to kill germ cells that are surrounded by a cell wall. Germ cells that do not have a cell wall, such as viruses, are not affected by soap.

The size of the soap micelles is important. Micelles that are too small will not be able to surround the germ cells. Micelles that are too large will not be able to penetrate the cell walls.

The concentration of soap is also important. A higher concentration of soap will be more effective at killing germ cells.

The temperature of the water can also affect the effectiveness of soap. Soap is more effective at killing germ cells in warm water than in cold water.

I hope this post has helped you understand the importance of handwashing and why doctors always ask you to do it regularly. Washing your hands with soap and water for at least 20 seconds is one of the best ways to prevent the spread of germs and stay healthy. So please, wash your hands often and help keep yourself and others safe!

Thank you for reading this post. I hope you found it informative and helpful. Please share it with your friends and family so they can learn about the importance of handwashing too. 😊🙏

Yersinia pestis

Yersinia pestis is the bacterium responsible for plague, with the most common manifestations being bubonic plague, septicemic plague, and pneumonic plague.

Image taken via transmission electron microscopy. Bar = 1 μm

Photo credit: Hans R. Gelderblom, Rolf Reissbrodt/RKI

Can a bat protein treat human inflammation?

A protein from bats shows promise for fighting inflammatory diseases in humans.

“Bats have attracted great attention as a likely reservoir of the SARS-CoV-2 virus responsible for the COVID-19 pandemic,” says Professor Wang Lin-Fa of the Duke-NUS Emerging Infectious Diseases (EID) Programme and senior author of the study in the journal Cell. “But this unique ability to host yet survive viral infections could also have a very positive impact on human health if we can understand and exploit how they achieve this.”

The research is focused on multi-protein complexes called inflammasomes that are responsible for the overactive inflammation that causes serious symptoms in many diseases. Inflammasomes are also implicated in functional decline in aging.

The researchers discovered that a bat protein called ASC2 has a powerful ability to inhibit inflammasomes, thereby limiting inflammation.

“This suggests that the high-level activity of ASC2 is a key mechanism by which bats keep inflammation under control, with implications for their long lifespan and unique status as a reservoir for viruses,” explains Matae Ahn, first author and co-corresponding author of the study and an adjunct research fellow with the EID Programme and the SingHealth Duke-NUS Medicine Academic Clinical Programme.

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this is the content i'm in the microscopy subreddit for

Physarum pulcherrimum + beetle

by Kim Fleming

FOTD #066 : cornflower bolete! (gyroporus cyanescens)

the cornflower bolete (AKA bluing bolete) is a species of bolete fungus in the family gyroporaceae. it is found in asia, australia, europe, & eastern north america. most often, this bolete grows on the ground in coniferous & mixed forests :-)

the big question : can i bite it??yes !! it is choice. there are many online tutorials on how to cook it, too.

g. cyanescens description :

"the yellowish to buff cap surface is fibrous & roughened, & reaches up to 12 cm (4.7 in) in diameter. the thick stem, roughly the same colour as the cap or lighter, is hollowed out into chambers. all parts of the mushroom turn an intense blue colour within a few moments of bruising or cutting."

[images : source & source] [fungus description : source]

How a novel class of sulfonamides potently blocks malaria transmission

Drugs to treat malaria symptoms and insecticides to kill malaria-spreading mosquitoes have improved in recent decades, but the parasite and the mosquitoes are evolving to become resistant to these strategies.

The Baum laboratory along with colleagues at Imperial College London, UK, previously identified a new class of potent antimalarial compounds, belonging to a family of sulfonamides. These compounds kill the parasite only when it is in a specific sexual phase of its life cycle, rapidly stopping it from being able to infect a mosquito and, therefore, preventing any subsequent human infection.

In their new Disease Models & Mechanisms article, Baum and colleagues explored exactly how these compounds work, which is an essential step before the compounds can be developed for testing in patients.

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