The Baum Laboratory Along With Colleagues At Imperial College London, UK, Previously Identified A New

How a novel class of sulfonamides potently blocks malaria transmission
Drugs to treat malaria symptoms and insecticides to kill malaria-spreading mosquitoes have improved in recent decades, but the parasite and the mosquitoes are evolving to become resistant to these strategies.

The Baum laboratory along with colleagues at Imperial College London, UK, previously identified a new class of potent antimalarial compounds, belonging to a family of sulfonamides. These compounds kill the parasite only when it is in a specific sexual phase of its life cycle, rapidly stopping it from being able to infect a mosquito and, therefore, preventing any subsequent human infection.

In their new Disease Models & Mechanisms article, Baum and colleagues explored exactly how these compounds work, which is an essential step before the compounds can be developed for testing in patients.

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More Posts from Mikrobiotch and Others

1 year ago

motivating myself to write my paper about fungi by talking about fungi:

in Tokyo in 2010, scientists wanted to test the limits of 'brainless' organisms, especially their decision making skills, so they made a little obstacle course in a Petri dish and sent a slime mold to navigate it. they set it up with light and oats, the oats acting as goals and the lights acting as deterrents. the oats were placed in such a way that represented the major train stations in Tokyo. in LESS THAN TWO DAYS, the slime mold had perfectly navigated the obstacle course and hit all the oat stations. when the scientists compared the Petri dish patterns to the city, they noticed that the slime mold had perfectly replicated the train lines of Tokyo. in the most efficient way possible. a task which took humans FIVE YEARS to plan, design and build. slime molds do not have nervous systems, brains, or (as it was previously believed) the ability to form complex thoughts. however, these molds were able to design this system quicker and more efficiently than humans ver have. they were even able to create a path for the shortest route through an IKEA.

the whole concept that organisms other than humans are unable to make decisions or solve complex problems is incredibly outdated and should have been disproven years ago when the Great Chain of Being was first challenged, but these ideas have stuck around for hundreds of years and are only now beginning to be opposed. for years, people thought that organisms like octopi could be tested on in labs because they were unable to feel pain or form thoughts, but only now is it being discovered that octopi have huge brains and are capable of numerous skills, they can recognize people and miss them, and they have the same or even better understanding of the world around them than humans. every other organisms' intelligence has been measured against humans for so long, that the idea that other creatures may have a different way of processing information is something completely unheard of.

in conclusion: brainless fungi and molds are redefining what humans believe to be 'intelligence' by exhibiting amazing navigation of obstacle courses, problem-solving and decision-making skills.


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2 years ago
Scientists Use Electricity to Make Wounds Heal 3x Faster
Scientists have developed a specially engineered biochip that uses electricity to heal wounds up to three times faster than normal.

It’s well known that electric fields can guide the movements of skin cells, nudging them towards the site of an injury for instance. In fact, the human body generates an electric field that does this naturally. So researchers from the University of Freiburg in Germany set out to amplify the effect.

While it might not heal severe injuries with the speed of a Marvel superhero, it could radically reduce the time it takes for small tears and lacerations to recover.

For people with chronic wounds that take a long time to heal, such as in elderly folk, those with diabetes, or people with poor blood circulation, recovering quickly from frequent small, open cuts could be a literal lifesaver.

“Chronic wounds are a huge societal problem that we don’t hear a lot about,” says Maria Asplund, a bioelectronics scientist at the University of Freiburg and Chalmers University of Technology in Sweden.

“Our discovery of a method that may heal wounds up to three times faster can be a game changer for diabetic and elderly people, among others, who often suffer greatly from wounds that won’t heal.”

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2 years ago

Mushrooms releasing spores into the wind. Captured by Paul Stamets

1 year ago
Rosalind Franklin was so much more than the ‘wronged heroine’ of DNA
nature.com
One hundred years after her birth, it’s time to reassess the legacy of a pioneering chemist and X-ray crystallographer.

At the centre of Rosalind Franklin’s tombstone in London’s Willesden Jewish Cemetery is the word “scientist”. This is followed by the inscription, “Her research and discoveries on viruses remain of lasting benefit to mankind.” As one of the twentieth century’s pre-eminent scientists, Franklin’s work has benefited all of humanity. The one-hundredth anniversary of her birth this month is prompting much reflection on her career and research contributions, not least Franklin’s catalytic role in unravelling the structure of DNA.

. . .

But Franklin’s remarkable work on DNA amounts to a fraction of her record and legacy. She was a tireless investigator of nature’s secrets, and worked across biology, chemistry and physics, with a focus on research that mattered to society. She made important advances in the science of coal and carbon, and she became an expert in the study of viruses that cause plant and human diseases. In essence, it is because of Franklin, her collaborators and successors, that today’s researchers are able to use tools such as DNA sequencing and X-ray crystallography to investigate viruses such as SARS-CoV-2.

. . .

Franklin was an inveterate traveller on the global conference circuit and a collaborator with international partners. She won a rare grant (with Klug) from the US National Institutes of Health. She was a global connector in the booming early days of research into virus structures: an expert in pathogenic viruses who had gained an international reputation and cared deeply about putting her research to use. It is a travesty that Franklin is mostly remembered for not receiving full credit for her contributions to the discovery of DNA’s structure. That part of Franklin’s life story must never be forgotten, but she was so much more than the “wronged heroine”, and it’s time to recognize her for the full breadth and depth of her research career.

1 year ago
Cortinarius Iodes And Marasmius Siccus
Cortinarius Iodes And Marasmius Siccus
Cortinarius Iodes And Marasmius Siccus
Cortinarius Iodes And Marasmius Siccus
Cortinarius Iodes And Marasmius Siccus
Cortinarius Iodes And Marasmius Siccus

Cortinarius iodes and Marasmius siccus

1 year ago
Predatory bacteria provide hope for chlorine-free drinking water
phys.org
In a unique study carried out in drinking water pipes in Sweden, researchers from Lund University and the local water company tested what wo

In a unique study carried out in drinking water pipes in Sweden, researchers from Lund University and the local water company tested what would happen if chlorine was omitted from drinking water. The result? An increase in bacteria, of course, but after a while something surprising happened: a harmless predatory bacteria grew in numbers and ate most of the other bacteria. The study suggests that chlorine is not always needed if the filtration is efficient—and that predatory bacteria could perhaps be used to purify water in the future. Just as human intestines contain a rich bacterial flora, many types of bacteria thrive in our drinking water and the pipes that transport them. On the inside of pipe walls is a thin, slippery coating, called a biofilm, which protects and supports bacteria. These bacteria have adapted to life in the presence of chlorine, which otherwise has the primary task to kill bacteria, particularity bacteria that can make humans sick.

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1 year ago
Silkworms Produce Spider Silk for the First Time - ChemistryViews
ChemistryViews
Spider silk by silkworms offers a green alternative to synthetic fibers

With the fast fashion industry… how it is… finding sustainable ways to make fabric is super important.  Fibers from synthetic fabrics make up 35% of the microplastics that make their way to the ocean.  Natural fibers sourced from plants or animals are much more environmentally sound options, including silk.

Currently, the only way to get natural silk on a large scale is to harvest it from silkworms.  You’ve probably heard about the strength and durability of spider silk (it is 6x stronger than Kevlar!) but as of yet there hasn’t been a good way of getting it.  Raising spiders the way people do silkworms isn’t really an option.  Spiders need a lot of room to build their webs compared to silkworms, and individual spiders don’t produce that much silk.  Plus, when you put a whole bunch of spiders in captivity together, they tend to start eating each other.

Attempts to artificially recreate spider silk have also been less than successful.  Spider silk has a surface layer of glycoproteins and lipids on it that works as a sort of anti-aging “skin”- allowing the silk to withstand conditions such as sunlight and humidity.  But this layer has been very tricky to reproduce.

However, as scientists in China realized, silkworms produce that same kind of layer on their silk.  So what if we just genetically modified silkworms to produce spider silk?

That is exactly what the researchers at Donghua University in Shanghai did.  A team of researchers introduced spider silk protein genes to silkworms using CRISPR-Cas9 gene editing and microinjections in silkworm eggs.  In addition to this, they altered the spider silk proteins so that they would interact properly with the other proteins in silkworm glands.  And it worked!  This is the first study ever to produce full length spider silk proteins from silkworms.

The applications of this are incredibly exciting.  In addition to producing comfortable textiles and new, innovative bulletproof vests, silkworm generated spider silk could be used in cutting edge smart materials or even just to create better performing sutures.  In the future, this team intends to research how to modify this new spider silk to be even stronger, and they are confident that “large-scale commercialization is on the horizon."


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1 year ago
Ode To The Microbe

Ode to the Microbe

Prints

1 year ago
Coelastrum, A Microalgae. 

Coelastrum, a microalgae. 

9 months ago

little creature of the day: Euglena gracilis

Little Creature Of The Day: Euglena Gracilis

micro organisms time

image source


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