Isocyanade - Blog Posts

This reminded me of the isonitrile freezer at my previous internship.

For those who don't know, isonitriles (aka isocyanides) are a class of compounds that contain this motif:

They are known to smell very bad and many synthesis pathways to those compounds were discovered because of their stench. (I personally think they smell like a mixture of rotten cabbage and burned rubber but more ''artificial'')

So in that lab, we had a freezer dedicated to them, and even with sealed bottles in à -20°C freezers in a separated and ventilated cabinet, you would still be able to detect their odour if you stood next to it (not strongly, but still detectable).

We had to move that freezer to a new lab, it stayed unplugged for 15 to 20 minutes, and in the 5 minutes we need to power it back in the new lab, the entire room had filled with that isonitrile stench (mind you that freezer had not been open during the entire operation). Thankfully we did that on a Friday afternoon and by Monday the smell had disappeared.

Just for reference this is from the MSDS of benzyl isonitrile :

found on a fridge in my lab, haha