Seriously, Genetics Is Weird.

Seriously, genetics is weird.

I was reading one paper on long noncoding RNAs and there's this one part that just really stood out to me.

So to catch everyone up, genetic data is stored as DNA. Then parts of it go through a process called transcription to build a strand of RNA. Certain RNAs get translated into proteins, but there are noncoding RNAs that don't make proteins but instead do a secret second thing (and I mean secret cause there are tons of ncRNAs that no one knows what they do). long noncoding RNAs are just noticeably longer than average.

Anyway, one lncRNA mentioned in the paper is called WINCR1. When the researchers managed to block it from being used, they noted that cells lost the ability to divide and there was one particular gene GADD45B, which is responsible for triggering apoptosis, was more common in the cells.

So my guess is one of WINCR1's jobs is to just confirm to the self-destruct system that the DNA isn't broken. Like, it being transcribed essentially tells the cell that that part of the DNA is still working and it can then go and turn off the kill switch.

So I guess cells are just designed to kill themselves as their default setting and WINCR1 is the drinking bird pressing the Y key to tell the system to not just blow up.

A scene from the Simpsons. A drinking bird toy repeatedly taps on the 'y' key on Homer's keyboard.

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